Dimethyl Sulfoxide
Apexbio Technology LLC YO-01027 (Dibenzazepine, DBZ) 209984-56-5 10mM (in 1mL DMSO)
YO-01027 (Dibenzazepine DBZ CAS 209984-56-5) is a potent inhibitor targeting -secretase a multimeric aspartyl protease involved in the proteolytic cleavage of type I integral membrane proteins notably amyloid precursor protein-like (APPL) proteins and Notch receptors YO-01027 interacts with the N-terminal regions of presenilin dose-dependently inhibiting cleavage of APPL and Notch proteins Research indicates that YO-01027 modulates cell differentiation by suppressing Notch signaling pathways influencing cellular transitions and mucin (MUC16) synthesis illustrating its utility in cell biology and therapeutic studies of Notch-related signaling processes
Apexbio Technology LLC WP1066 857064-38-1 10mM (in 1mL DMSO)
WP1066 (CAS 857064-38-1) is a small molecule analog of AG490 and functions primarily as an inhibitor of Janus kinase 2 (JAK2) It disrupts JAK2 signaling by reducing phosphorylation and promoting degradation of the JAK2 protein thereby inhibiting downstream STAT3/STAT5 transcription factors and the phosphoinositide-3 kinase pathway WP1066 has demonstrated antiproliferative and pro-apoptotic activity in models of acute myeloid leukemia (AML) including patient-derived AML cells and AML cell lines (OCIM2 K562) Additionally WP1066 shows inhibitory effects against tumor growth and angiogenesis in renal cell carcinoma (RCC) model systems highlighting its potential for hematologic cancers and RCC therapeutic research
Apexbio Technology LLC Vidarabine 5536-17-4 10mM (in 1mL DMSO)
Vidarabine is an antiviral nucleoside analog widely studied for inhibiting replication of herpes simplex virus (HSV) and varicella-zoster virus (VZV) Structurally vidarabine is an adenine arabinoside analog that interferes with viral DNA synthesis via competitive inhibition of viral DNA polymerase resulting in chain termination In vitro studies demonstrate antiviral activity against HSV type 1 and type 2 with IC50 values typically ranging approximately from 0 1 to 1 0 M depending on experimental conditions and viral strains Vidarabine is commonly used in biomedical laboratories for investigating viral replication mechanisms screening for antiviral candidates and elucidating nucleoside analog resistance patterns
Apexbio Technology LLC Chidamide(Synonyms: Epidaza, HBI-8000, CS055, Tucidinostat, Entinostat analog, Chidamide (CS055)), 10mM (in 1mL DMSO), CAS: 743420-02-2.
Chidamide (CAS 743420-02-2) is a benzamide-based histone deacetylase (HDAC) inhibitor that targets enzymes responsible for the reversible acetylation of lysine residues on histone tails By modulating HDAC activity Chidamide promotes chromatin remodeling influencing transcription factor access and subsequent gene transcription In vitro studies on human leukemia cell lines and primary myeloid leukemia cells indicate that Chidamide induces cell cycle arrest at the G1 phase differentiation and apoptosis via ROS-dependent mechanisms Therefore Chidamide shows considerable potential in research focused on hematologic malignancies and cancer therapy
Medchemexpress LLC Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 100.0% | 78.13 | C2H6OS | 200mL
Dimethyl sulfoxide (DMSO) is an aprotic solvent that can dissolve water-insoluble therapeutic and toxic agents Dimethyl sulfoxide (DMSO) has a strong affinity for water and has the ability to rapidly penetrate or enhance the penetration of other substances through biological membranes Dimethyl sulfoxide also has potential free radical scavenging and anticholinesterase effects and may affect coagulation activity Dimethyl sulfoxide also induces histamine release from mast cells but is thought to have low systemic toxicity[1] br/ Low endotoxin can be used in various biochemical experiments such as drug dissolution
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide | 67-68-5 | MFCD00002089 | 4 x 2 mL
Dimethyl sulfoxide | Purity: ≥99.9% | Mol Wt: 78.13 | 67-68-5 | MFCD00002089 | 4 x 2 mL
Apexbio Technology LLC Trametinib DMSO solvate 1187431-43-1 10mM (in 1mL DMSO)
Trametinib DMSO solvate (CAS 1187431-43-1) is a potent allosteric inhibitor of MEK1 and MEK2 that acts through an ATP-noncompetitive mechanism In preclinical models it has demonstrated broad antitumor activity notably in colorectal cancer cell lines such as HT-29 and COLO205 Trametinib induces the expression of p15 and p27 suppresses cyclin D1 promotes RB dephosphorylation and G1 cell cycle arrest and reduces thymidylate synthase expression Furthermore it inhibits ERK1/2 phosphorylation leading to growth suppression in B-RAF mutant tumor cells Trametinib serves as a valuable tool for studying MAPK pathway signaling and targeted cancer therapeutics
Apexbio Technology LLC Cediranib (AZD217) 288383-20-0 10mM (in 1mL DMSO)
Cediranib (AZD2171 CAS 288383-20-0) is an orally bioavailable small molecule inhibitor targeting the kinase insert domain receptor (KDR VEGFR-2) with potent inhibition observed in recombinant assays (IC50 1 nM) Additionally cediranib suppresses related vascular endothelial growth factor receptors VEGFR-1 (Flt-1 IC50 5 nM) and VEGFR-3 (Flt-4 IC50 3 nM) It also blocks select platelet-derived growth factor receptors notably c-Kit PDGFR PDGFR and CSF-1R at nanomolar to sub-micromolar concentrations indicating multiple-kinase targeting capability Cediranib serves as a valuable research compound for studying tumor angiogenesis and kinase-driven oncogenic pathways
Apexbio Technology LLC BKM120 944396-07-0 10mM (in 1mL DMSO)
BKM120 (CAS 944396-07-0) is a potent orally bioavailable inhibitor of class I phosphatidylinositol 3-kinases (PI3Ks) specifically targeting the isoforms p110 p110 p110 and p110 with IC50 values of 52 nM 166 nM 262 nM and 116 nM respectively By blocking PI3K activity this molecule suppresses downstream phosphorylation of AKT an important mediator within the PI3K-AKT-mTOR signaling cascade implicated in tumor growth and survival Preclinical studies demonstrate that BKM120 restricts tumor cell proliferation promotes cell cycle arrest at G1 phase and induces apoptosis particularly noted in PTEN-deficient cancer models Thus BKM120 serves as a useful tool for studying PI3K pathway-dependent cancers
Apexbio Technology LLC Crenolanib (CP-868596)(Synonyms: CP-868596, Crenolanib besylate, AR-868596, PDGFR inhibitor CP-868596, PDGFR-beta inhibitor CP-868596), 10mM (in 1mL DMSO), CAS: 670220-88-9.
Crenolanib (CP-868596 CAS 670220-88-9) is a selective inhibitor targeting receptor tyrosine kinases PDGFR PDGFR and FLT3 exhibiting Kd values of 3 2 nM 2 1 nM and 0 74 nM respectively It notably suppresses the FLT3 autophosphorylation and proliferation mediated via PDGFR mutations that confer resistance to imatinib such as D842V (IC50 10 nM) but does not inhibit the V561D mutant Additionally crenolanib reduces kinase activity of the FIP1L1-PDGFRA fusion protein (IC50 1 nM) and proliferation in EOL-1 cells It serves as a research tool for kinase-driven malignancies particularly those resistant to other kinase inhibitors
Gold Biotechnology Inc Sterile Filtered DMSO
Dimethylsulfoxide (DMSO) is a very polar organic compound that is useful in organic chemistry for solubilizing organic and inorganic compounds DMSO is also used as a cryoprotectant for cell media preventing the formation of ice crystals which would otherwise damage cells DMSO can be used in PCR reactions to inhibit the self-complementation of DNA or PCR primers and increase amplification especially for DNA sequences which have GC rich sequences
Apexbio Technology LLC Tenofovir Disoproxil Fumarate 202138-50-9 10mM (in 1mL DMSO)
Tenofovir disoproxil fumarate is an antiviral nucleotide analog functioning as a nucleoside reverse transcriptase inhibitor (NRTI) Upon cellular uptake it undergoes enzymatic hydrolysis to form the active metabolite tenofovir subsequently phosphorylated to the diphosphate derivative This phosphorylated metabolite competitively inhibits HIV-1 reverse transcriptase and induces DNA chain termination In vitro studies using MT-2 cells and peripheral blood mononuclear cells (PBMC) have demonstrated suppression of HIV replication with reported EC50 values approximately 0 007 mol/L and 0 005 mol/L respectively This compound is routinely utilized in research investigating HIV replication mechanisms antiretroviral therapies and drug resistance profiles
Sigma Aldrich Fine Chemicals Biosciences Cell freezing Medium-DMSO
Cell freezing medium is a combination of cryoprotectant DMSO with fetal bovine serum. However serum free medium replaces serum with methylcellulose and poloxamer 188 and other additives like ascorbic acid tocopherol and proline.
Apexbio Technology LLC Tariquidar(Synonyms: XR9576, Tariquidar fumarate, XR-9576, UNII-1W8830WSA2, P-glycoprotein inhibitor XR9576), 10mM (in 1mL DMSO), CAS: 206873-63-4.
Tariquidar (CAS 206873-63-4) is a small-molecule inhibitor targeting the efflux transporter P-glycoprotein (Pgp) Pgp a 170-kDa transmembrane protein functions primarily as an ATP-dependent drug efflux pump removing structurally diverse molecules from cells Tariquidar acts through noncompetitive inhibition of Pgp-associated basal ATPase activity thereby reducing drug efflux In vitro assays across several cell models demonstrate tariquidar-mediated Pgp inhibition with IC50 values ranging from 15 to 223 nM Due to its selectivity for Pgp tariquidar serves as a significant research tool in studies of drug resistance and transporter-mediated drug disposition
Apexbio Technology LLC GYY 4137 morpholine salt(Synonyms: GYY4137, Morpholin-4-ium 4-methoxyphenyl(morpholino)phosphinodithioate, GYY-4137), 10mM (in 1mL DMSO), CAS: 106740-09-4.
GYY 4137 morpholine salt (CAS 106740-09-4) is a slow-releasing hydrogen sulfide (H S) donor that exerts biological activity by modulating signaling pathways involved in vasodilation and blood pressure regulation In experimental studies this compound demonstrates the capacity to suppress cellular proliferation induce apoptosis and arrest cell cycle progression Due to these properties GYY 4137 morpholine salt is widely utilized in research investigating hypertension inflammation and cancer biology