Dimethyl Sulfoxide
Crescent Chemical Co Inc Dimethyl Sulfoxide, 67-68-5, MFCD00002089, 250mL
Molecular Formula C2H6OS, Molecular Weight 78.134, Molecular Biology Grade, DNase/RNase not detected. Storage Conditions: +15 °C TO +30 °C
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide PCR Reagent | 67-68-5|MFCD00002089 | 1vl
Dimethyl sulfoxide PCR Reagent | Mol Wt: 78.13 | 67-68-5MFCD000020891 | vl
Selleck Chemical LLC Trametinib DMSO solvate S4484-1g
Trametinib DMSO solvate is a highly specific and potent MEK1/2 inhibitor with IC50 of 0 92 nM/1 8 nM in cell-free assay Trametinib activates autophagy and induces apoptosis
Medchemexpress LLC Ocedurenone 10 mM 1 mL in DMSOSolid Solvent
Ocedurenone 10 mM*1 mL in DMSOSolid + Solvent
Sigma Aldrich Fine Chemicals Biosciences Dimethyl sulfoxide anhydro1L
Dimethyl Sulfoxide is an apolar protic solvent that is generally used as a reaction medium and reagent in organic reactions.
Apexbio Technology LLC DMXAA (Vadimezan) 117570-53-3 10mM (in 1mL DMSO)
DMXAA (Vadimezan AS-1404) is a tumor vascular disrupting and apoptosis-inducing agent functioning primarily through inhibition of DT-diaphorase (DTD) It acts by suppressing DTD enzymatic activity showing an IC50 of approximately 62 5 M Additionally DMXAA inhibits various kinases notably VEGFR2 disrupting endothelial cells and blood vessel formation to induce tumor cell apoptosis and vascular necrosis Experimentally DMXAA demonstrates activity in murine tumor models including induction of apoptosis in endothelial cells and tumor vasculature promoting necrosis and tumor regression Therefore DMXAA is commonly used in oncology research focused on anti-angiogenesis and tumor vascular disruption mechanisms
Apexbio Technology LLC Lonidamine 50264-69-2 10mM (in 1mL DMSO)
Lonidamine (AF-1890) is a cell metabolism inhibitor targeting mitochondrial pyruvate carrier and hexokinase exhibiting inhibitory activity with a Ki value of approximately 2 5 M Through these targets it disrupts glycolytic metabolism by impairing aerobic glycolysis processes common in tumor cells Researchers utilize Lonidamine primarily to investigate metabolic pathways implicated in cancer cell energy production alterations in mitochondrial functions and related metabolic disorders Additionally Lonidamine is employed experimentally in studies examining mitochondrial dysfunction-associated conditions and inflammatory responses including pulmonary fibrosis
Apexbio Technology LLC XL019 945755-56-6 10mM (in 1mL DMSO)
XL019 (CAS 945755-56-6) is a selective inhibitor targeting Janus kinase 2 (JAK2) with an IC50 of 2 2 nM JAK2 regulates signaling pathways controlling erythroid granulocytic and megakaryocytic lineage differentiation via cytokine and hematopoietic growth factor receptors including erythropoietin and thrombopoietin receptors XL019 demonstrates high selectivity for JAK2 over related kinases (e g JAK1 TYK2) In mouse models bearing HEL 92 1 7 xenografts oral administration of XL019 significantly reduced tumor growth XL019 is evaluated clinically as a candidate for treating primary myelofibrosis and secondary myelofibrosis associated with polycythemia vera or essential thrombocythemia
Apexbio Technology LLC Kaempferol(Synonyms: Kempferol, Kaempherol, Kaempferide, Robigenin, Rhamnolutein, Populnetin), 10mM (in 1mL DMSO), CAS: 520-18-3.
Kaempferol (CAS 520-18-3) is a naturally derived flavonoid isolated from sources including Gingko biloba and red wine It functions biologically by activating the mitochondrial calcium uniporter (EC50 7 M) Additionally kaempferol promotes apoptosis through the caspase-9 pathway by suppressing polo-like kinase 1 (PLK1) expression thereby inhibiting cancer cell proliferation in diverse cell lines It also demonstrates antioxidant properties and reduces osteoclast-mediated bone resorption in vitro These characteristics make kaempferol valuable for researching mitochondrial physiology cancer biology and bone metabolism
Apexbio Technology LLC GZD824 1421783-64-3 10mM (in 1mL DMSO)
GZD824 (CAS 1421783-64-3) is an orally bioavailable inhibitor of the Bcr-Abl kinase a fusion protein exhibiting tyrosine kinase activity involved in regulating cell cycle progression and genomic stability GZD824 binds competitively to the ATP-binding site of Abl kinase effectively inhibiting the phosphorylation and activation of both wild-type (WT) and resistant mutant forms (e g T315I E255K G250E Q252H H396P M351T and Y253F) GZD824 demonstrates sub-nanomolar IC50 values and substantially reduces proliferation in Bcr-Abl-expressing Ba/F3 cell models Preclinical studies in mouse xenograft leukemia models show GZD824 suppresses tumor growth highlighting its potential applicability in research into resistance mechanisms and targeted leukemia therapies